no association of folate- related and methionine synthesis genes variant in the development and progression of childhood all among north indian population

introduction: acute lymphoblastic leukemia (all ) is the most worldwide common type of childhood cancer. methylenetetrahydrofolate reductase (mthfr) and 5-methyltetrahydrofolate-homocysteine methyltransferase (mtr) are crucial enzymes in folate pathways. folate availability is critical factor for dna integrity, required for the transfer of methyl group in the biosynthesis of thymidilate. procedure: in present study, we have conducted a case control study from north indian states   to correlate the effect of two snps of mthfr (677c→t and 1298a→c) and mtr (2756a→g) and the risk of childhood all. one hundred and twenty five bone marrows and peripheral blood samples and 100 sex-age matched healthy controls were obtained and analyzed by pcr-rflp method. results: statistically, no significant differences were observed between patients and controls for different genotypes (p>0.05), also significant different on risk of all in individuals having genotype of mthfr 677tt (or=0.61, 95% ci=0.21-1.77) and mthfr 1298cc (or=0.56, 95% ci=0.18-1.68) was not observed. statistically, the correlation of variants of mtr gene and risk of all was not observed. conclusions: the difference in distribution of possible combined genotypes of mthfr (677c→t, 1298a→c) and mtr (2756a→g) between patients and controls were statistically insignificant.